Phone office Email keith. If you made any changes in Pure these will be visible here soon. Personal profile. Gideon Davies, University of York Dr. Brian Mark, University of Manitoba Dr. Alisdair Boraston, University of Victoria Dr. Charlene Kahler, University of Western Australia.
Carbohydrates are present in every living system from prokaryotes to eukaryotes and traditionally, have been known for their role in the structural integrity of plants and as energy sources. Recently, however, carbohydrates have been shown to be involved in a variety of fundamental biological processes such as protein folding and trafficking, as well as cellular signaling and recognition.
As we gain greater understanding into the roles that carbohydrates play at the cellular level, scientists are faced with new challenges. On the chemistry side, unique carbohydrate-based tools need to be developed and in turn used to investigate the specific roles that a single mono- or polysaccharide plays in the dynamics of the cell in order to keep up with the biochemical discovery of new glycan structures and the enzymes that regulate them.
My research aims are to address the development of such tools which involves synthetic, medicinal and biochemical approaches. Very brief overviews of current research areas are outlined below.
Developing tools to study carbohydrate-processing enzymes in human health and disease: Various human diseases are caused by improper function of a specific carbohydrate-processing enzyme. We aim to develop tools to study these enzymes and then use the information gathered to produce therapeutics. This is done through the use of synthetic and medicinal chemistry approaches. We have numerous collaborators in Canada and the UK working with us on these projects. Investigations into human milk oligosaccharides: One class of carbohydrates is those found in human breast milk and are termed human milk oligosaccharides HMOs.
These compounds are critical for infant health as they provide nutrition for bifidobacteria found in the human intestinal tract which provide great benefits to infants such as nutrients, prevention of pathogenic bacterial growth and suppression of inflammatory and allergic responses.
To date though, limited chemical tools have been generated to study these fundamentally important molecules. We have several collaborators in Japan working with us on this project.
Antimicrobial resistance: As the threat of antibiotic resistance grows with each passing year new therapeutic targets are required. We have numerous targets and approaches to developing new therapeutics. We have numerous collaborators in Australia and Canada working with us on these projects. Investigations into the mechanism and biochemistry of carbohydrate-processing enzymes involved in plant cell wall degradation: Of increasing interest is how bacteria utilise plant-based materials and their direct importance to humans, as we are only able to utilise these carbohydrates for metabolism due to the action of unique enzymes produced by the bacteria living in our gastrointestinal tract.
Herbicide resistance: The development and use of herbicides in agriculture has improved crop yields worldwide, but like antimicrobial resistance, herbicide resistance is also highly prevalent and is threatening food production. In collaboration with Professor Joshua Mylne UWA we have discovered new compounds with herbicidal potency and methods to assess the ability of these compounds to act as herbicides in the field.
This project offers exciting opportunities in synthetic organic and medicinal chemistry. Microfluidics: The development of new methodology in organic chemistry is always required to improve reaction yields and discover new reactions.
In collaboration with Professor Colin Raston we have a microfluidic platform that can be utilized to explore new chemical reactions and also develop methodology to improve on existing methodologies. This project offers exciting opportunities in general synthetic organic chemistry.
In the process, Stubbs also became a restaurateur, which he terms both exciting and overwhelming. Noelle helped with the menu, "making sure he added some salads," she said. Contacts developed from years of performing have helped Stubbs book top-tier talent in his Utah clubs. Just as important, he has earned a track record of breaking comics such as Carlos Mencia, Lewis Black and Frank Caliendo in this market years before they became famous.
McHale was particularly grateful for the gig, as at the time, he had no stand-up experience. Although McHale's agent just wanted him to emcee the show, Stubbs took a risk.
Sensing that McHale was a star in the making, Stubbs booked him for two shows -- and because those sold out so quickly, he added two more. Besides attracting big names like Tom Arnold, who performed at the West Valley City club on Friday, Stubbs has helped young, local comics on their acts.
Rodney Norman, who now lives in Connecticut and performs stand-up in New York City and Boston, credits Stubbs for helping start his career. After performing in Kansas City for a year, Norman moved to Utah and became the house emcee for several years at the West Valley club. Stubbs spent hours mentoring him on what it takes to make an audience giggle or guffaw. As a club owner, Stubbs' approach differed from those clubs that initially snubbed him, Norman said.
Incidentally, all of those clubs have since closed down. He was the first to work with local talent and help them. Because he's good-natured onstage, some might underestimate his business savvy, said Dee Dee Hill, general manager of local ticket broker SmithsTix. He has a good relationship with comics and comics' agents because he knows how they want to be treated. On top of that, he pays comics on time, treats them professionally -- and when comics are happy, audiences are happy, she said.
Most important, Stubbs has ambition, a quality that helps in the business world. He has built these clubs that bring in nationally touring comedians and more local talent that any other place I've been. He uses so much local talent, so he takes risks all the time. Taking a risk on Stubbs was Simmons Media, which has featured the comedian as a morning radio host for more than four years.
He is just a funny human being. He's a natural talent and entertainer. We're lucky to have him. Being on the radio every weekday morning keeps him fresh, Stubbs said, something he employs in his always-evolving stand-up act. That's why he continues to be a successful stand-up comic, according to those in the business who continue to learn from him.
No matter how serious he is about the comedy business, in an interview he underscores that he wants to be known for his act. He knows there's little respect in comedy. When he told his mother and some of his Mormon friends he was changing careers, "the reaction was like I was a stripper. Drumroll, please. Legal Notices Obituaries Jobs Homes. The king of Utah comedy: Keith Stubbs hones talent while running four clubs and hosting radio show. Comedians who have performed at WiseGuys clubs in Utah.
Margaret Cho. Louis Black. Bill Burr. Louis CK.
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