This pilot trial will recruit type 2 diabetic subjects already on metformin and treat them with chromium picolinate for 8 weeks. The results of the trial will provide vital preliminary data including safety and size of effect to direct future, larger studies.
Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies. XX for two years or less and treated with metformin Patients having completed dose titration of metformin as prescribed by their physician and have reached a stble dose between mg per day for at least two months HbA1c: 7. Clinical or objective finding suggestive of congestive heart failure. Women of child-bearing age not using standard birth control measures. Isolated LFT elevations with an ultrasound diagnosis of non-alcoholic Steatohepatitis and a lab rule out of viral hepatitis will be included in the study with careful monitoring of LFTs.
Subjects currently taking nutritional supplements, including multivatmin for study duration; subjects will be asked to discontinue any nutritional supplementation at the screening telephone interview 1 week prior to screening lab work and 4 week sprior to baseline lab work.
Subjects taking lipid lowering medications except statins i. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms. Save this study. Warning You have reached the maximum number of saved studies Pilot Trial of Chromium-Metformin Combination in Type 2 Diabetes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. This salt combination may also be used for purposes not listed in this medication guide.
Report your Use ». Learn more: Uses. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious.
Consult your doctor if you observe any of the following side-effects, especially if they do not go away. If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. Report Side-effects ». Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert.
Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below. Aluminum toxicity Blurred vision Diabetic ketoacidosis Do not overdose Severe kidney disease Symptoms like nausea, vomiting, abdominal pain, fatigue, anorexia and dark urine. This may increase your risk for side-effects or cause your drug not to work properly.
Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Acute myocardial infarction Cardiovascular collapse Diabetic ketoacidosis Hypersensitivity Intramuscular injection of Chromium Intravenous injection of Chromium Renal disease Septicemia.
However, we as scientists and clinicians cannot dismiss the current body of work that indicates the efficacy of this mineral, nor should we dismiss consumer support for this product as being without merit.
Glucose and insulin responses to dietary chromium supplements: a meta analysis. Am J Clin Nutr ; 76 : — Google Scholar. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.
Diabetes ; 46 : — Effects of chromium picolinate on insulin levels and glucose control in obese patients with type-II diabetes mellitus. Diabetes ; 48 suppl : A abstr. Effect of chromium picolinate on insulin sensitivity in vivo. J Trace Elem Exp Med ; 12 : 71 — Follow-up survey of people in China with type 2 diabetes mellitus consuming supplemental chromium. J Trace Elem Exp Med ; 12 : 55 — Evans GW. The effect of chromium picolinate on insulin controlled parameters in humans.
Int J Biosoc Res ; 11 : — Chromium supplementation for women with gestational diabetes mellitus. J Trace Elem Exp Med ; 12 : 91 — 7. Diabetes Care ; 17 : — Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium.
Diabet Med ; 16 : — 7. Clinical use of the trace element chromium III in the treatment of diabetes mellitus. J Trace Elem Exp Med ; 8 : — Anderson RA.
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